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Microsomal Stability Assay Analysis
• Your Assay Methods
• No MRM Required
• 3 Day Turnaround
• Free Demonstration
Analysis
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High Correlation of
RF-TOF to LC-MS/MS
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Home / Contract Research / in vitro ADME Screening / Microsomal Stability ...
RapidFire® Microsomal Stability Analysis Service
[Your Assay + Our Analysis] = Faster Results
Assays that measure microsomal stability are used to predict metabolic clearance early in drug discovery in order to eliminate poor performers and/or to identify compounds that require modification. Mass spectrometry is the preferred analysis method for this assay due to its sensitivity, specificity and robustness.
However, microsomal stability assays are usually analyzed using tandem MS, which is limited by its requirement for compound dependent method development. BIOCIUS offers a faster and more efficient solution to the analysis of these assays that still leverages the strengths of mass spec analysis.
With a more than 10x increase in sample throughput and the use of accurate mass time-of-flight mass spectrometers, your analysis is completed and data delivered to you within 3 days. Laborious sample preparation is not required—simply send BIOCIUS quenched 96 or 384 well plates.
Contact us for a no-cost, no-obligation Demonstration Analysis of your assays.
The RapidFire Microsomal Stability Analysis Service uses accurate mass time-of-flight (TOF) mass spectrometers, (thus eliminating the need for MRM method development), in conjunction with the RapidFire SPE-MS sample preparation system. Microsomal stability assay results from the RapidFire system correlate very well with results from conventional LC-MS/MS systems (Hatsis, et. al, 2010 & Luippold et. al, 2010, see charts at right).
Fast turnaround times and data that is compatible with laboratory LIMS further increases productivity. RapidFire services require no alterations to existing laboratory workflows, ensuring a seamless and efficient integration for researchers.
BIOCIUS’s experienced scientists have screened millions of wells for our clients in the pharmaceutical and biotechnology industries in support of their drug discovery efforts. RapidFire Contract Research Services enable researchers to:
- increase efficiency of laboratory resources
- obtain more data faster without compromising assay integrity
- make better informed decisions
BIOCIUS. Faster Answers.
RapidFire® technology is described in patent numbers 6,932,939, 6,812,030 7,100,460, 7,588,725,