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RF 300 System
RF 300 is optimized for round the clock operation and allows separate screening methods for each plate.
Cartridge Cassette for RF 300
Capable of loading 6 columns at once for 24-hour operation.
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RF 300 for in vitro ADME and High Throughput Screening
Faster ADME data - No compromises in assay integrity
The RF 300 Mass Spectrometry System (RF-MS) is optimized for in vitro ADME applications. The latest addition to the RapidFire instrument portfolio has been developed to address the bottleneck of in vitro ADME assays that face researchers today.
RF 300 System Features
- Label-free detection—detection of native compounds without the need for fluorescence, luminescence or radioactivity.
- Unattended 24-hour operation—automated cartridge changing hardware and integrated optical sensors automatically detect fluid flow and the software flags any aberrant samples.
- Advanced plate mapping functionality—enables flexibility to use separate screening methods for each individual plate well.
- Integrated sample preparation—no up-front sample preparation required.
- Multiple cartridge chemistries available.
In vitro ADME Applications
- CYP Inhibition
- Metabolic Stability
- P-glycoprotein Inhibition (Digoxin)
- Plasma Protein Binding
- Permeability (Caco-2 and PAMPA)
- CYP Induction
The RF 300 uses a cartridge cassette that enables loading of six columns at once for 24-hour unattended operation or method development using multiple chemistries per run.
BIOCIUS. Faster Answers.
RapidFire® technology is described in patent numbers 6,932,939, 6,812,030 7,100,460, 7,588,725,