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Presentations and Posters

These are listed chronologically with the most recent first. To view a list of publications organized by in vitro ADME or Lead Discovery topics, please visit our "Resources" overview page.

RapidFire Poster: Epigenetic Targets
High Throughput Mass Spec Detection of Histone 3 Demethylation

ALA 2010 Presentation Slides
RF300: an integrated, automated SPE‐MS system for high‐throughput ADME sample analysis.

RF300 Poster at the 2009 ELRIG meeting
Consistent, High-throughput Metabolic Stability Screening Across Mass Spectrometry Platforms

Presentation by Debbie Zink, Merck (User Symposium held at ASMS 2009)
"The Application of RapidFire MS in a High-throughput Production Assay Lab"

Presentation by Andreas Luippold, Boehringer-Ingelheim (User Symposium held at ASMS 2009)
"A Novel and Integrated Platform for Fully Automated High Throughput LC-MS/MS Analysis of in vitro ADME Sample"

ASMS 2009 Posters

Bristol-Myers Squibb Poster at the 2009 ASMS meeting
Application of the BioTrove RapidFire Ultra-fast, Online, SPE-MS-MS System for Compound-specific Analysis of in vitro ADME Samples

RF-TOF Poster at the 2009 ASMS meeting
Evaluation of Accurate Mass TOF-MS for use in High-throughput CYP450 Inhibition Screening

GSK Poster at the 2009 ASMS meeting
Label-free High-throughput Whole Protein Kinase Screening Assay

OSI Poster at the 2009 ASMS meeting
Discovery of Novel Inhibitors of Serine Palmitoyltransferase (SPT) by Mass Spectrometry-based High-throughput Screening (HTS)

ISSX-Europe 2009 Posters

BD Poster at the 2009 ISSX European meeting
Comparison of RapidFire Ultra High-throughput LC/MS/MS with Traditional LC/MS/MS for Cytochrome P450 Inhibition Testing

BD Poster at the 2009 ISSX European meeting
Evaluation of High-throughput Screening Methods for Time Dependent Inhibition of CYP3A4 Utilizing RapidFire LC/MS/MS Technology

SBS 2009 Posters

Genzyme Poster at the 2009 SBS meeting
Discovery of Small Molecule Inhibitors of GM3 Synthase via High Throughput Mass Spectroscopy

Poster presented at the 2009 SBS meeting
Consistent High-throughput CYP Inhibition Data Across Mass Spectrometry Platforms

SBS Tutorial Presentation
RapidFire High-throughput Mass Spectrometry Solution for Label-free Functional Assays

Other Posters and Presentations

Exelixis Presentation at 2008 SBS meeting
CYP450 Inhibition Profiling Using High Throughput RapidFire® Mass Spectrometry Assays

Agilent Application Note
Ultra-high throughput determination of CYP450 enzyme inhibition through mass spectrometry

Astra-Zeneca Presentation at 2007 AAPS meeting
Comparison of RapidFire® uHTMS and Traditional LCMS/MS Analysis to Assess Cytochrome P450 Inhibition Utilizing Clinically Relevant Probe Substrates

Pfizer Research Technology Center Poster from 2006 ISSX meeting
High-Throughput Mass Spectrometry-Based Screening to Identify Selective CYP3A5 Inhibitors

Pfizer Presentation at 2008 SBS meeting
The Use of High Throughput Mass Spectrometry (HTMS) in Drug Discovery

Amgen Presentation at 2008 Protein Society meeting
Screening For ATP Citrate Lyase Inhibitors Using Mass Spectrometry

Presentation at 2008 ASMS meeting
Direct Coupling of Non-Reverse-Phase Liquid Chromatography (LC) with Mass Spectrometry (MS) Utilizing RapidFire® Technology

Presentation at 2008 ASMS meeting
Real-Time Enzyme Kinetics Using RapidFire® Kinetics (RF-MS Kx) with an Agilent 6410 QqQ

Merck Presentation at 2007 SBS meeting
Identification of Inhibitors for the Phosphatidylethanolamine N-methytransferase Enzyme by High-Throughput Mass Spectrometry Detection of Reaction Products

Bayer Presentation at 2007 SBS meeting
High-Throughput Mass Spectrometry Screening for Inhibitors of Phosphatidylserine Decarboxylase

Schering Plough Research Institute Poster from 2006 SBS meeting
Screening LpxC (UDP-3-O-(R-3-hydroxymyristoyl)-GlcNAc deacetylase) using RapidFire® HTS Mass Spectrometry

Pfizer Poster from 2006 SBS meeting
Identification of Fatty Acid Amide Hydrolase Inhibitors by a High Throughput Mass Spectrometry-Based Assay

Bayer Poster from 2006 SBS meeting
Label-Free High-Throughput Screening by Mass Spectrometry

Sirtris Pharmaceuticals Poster from 2006 SBS meeting
Development of a High Throughput SIRT1 Mass Spectrometry Assay

BlueSky BioTech Poster from SBS 2006 meeting
Label-Free Screening of Acetyl-CoA Carboxylase from an Enriched Rat Liver Fraction

BlueSky BioTech Poster from SBS 2006 meeting
Label-Free Screening of Stearoyl-Coenzyme A Desaturase from an Enriched Rat Liver Fraction

Presentation at 2008 Assay Development & Screening Technologies Conference (GTC Bio meeting)
This presentation details the use of the RapidFire® high-throughput mass spectrometry platform in primary drug-screening applications.  Several key examples from the literature are included.
To request a copy of this presentation, click here

Amgen Presentation at 2006 ScreenTech meeting
This presentation details work performed at Amgen validating the RapidFire® high-throughput mass spectrometry platform via comparison to both HTRF and fluorescence polarization technologies.  Screening of the Lck kinase target was used as the basis for this comparion.
To request a copy of this presentation, click here


BIOCIUS. Faster Answers.

RapidFire® technology is described in patent numbers 6,932,939, 6,812,030 7,100,460, 7,588,725,