ADME Publications

Bristol-Myers Squibb Poster at the 2010 ASMS meeting
Development of a High-Throughput MS-Based Bioanalytical Method for Assessment of P-Glycoprotein Inhibition

RapidFire Poster at NE Drug Metabolism Discussion Group 2010
The End of MRM: Utlrafast SPE-based TOF Analysis of ADME Assays

RapidFire Poster at ASMS 2010
Evaluation of Accurate Mass TOF-MS for Use in High Throughput PAMPA & Plasma Protein Binding Screens

ALA 2010 Presentation Slides
RF300: an integrated, automated SPE‐MS system for high‐throughput ADME sample analysis.

Journal Article, March 2010, J.Biomol Screening
Development of a High-Throughput Online Solid-Phase Extraction/Tandem Mass Spectrometry Method for Cytochrome P450 Inhibition Screening

RapidFire Poster at 2010 SBS
High-throughput in Vitro ADME Assay Panel: Incorporation of SPE/MS/MS in Standard Laboratory Workflow

User Symposium Talks at ASMS 2009
"The Application of RapidFire MS in a High-throughput Production Assay Lab", Debbie Zink, Merck

User Symposium Talks at ASMS 2009
"A Novel and Integrated Platform for Fully Automated High Throughput LC–MS/MS Analysis of in vitro ADME Sample." Andreas Luippold, Boehringer-Ingelheim

BD Posters presented at 2009 ISSX Europe
Comparison of RapidFire Ultra High-throughput LC/MS/MS with Traditional LC/MS/MS for Cytochrome P450 Inhibition Testing

Poster presented at 2009 SBS
Consistent High-throughput CYP Inhibition Data Across Mass Spec Platforms

Bristol-Myers Sqiubb Poster at 2009 ASMS
Application of the RapidFire Ultra-fast, Online, SPE-MS-MS System for Compound-specific Analysis of in vitro ADME Samples

Exelixis Presentation at 2008 SBS meeting
CYP450 Inhibition Profiling Using High Throughput RapidFire® Mass Spectrometry Assays

Agilent Application Note
Ultra-high throughput determination of CYP450 enzyme inhibition through mass spectrometry

Astra-Zeneca Presentation at 2007 AAPS meeting
Comparison of BioTrove RapidFire® uHTMS and Traditional LCMS/MS Analysis to Assess Cytochrome P450 Inhibition Utilizing Clinically Relevant Probe Substrates

Pfizer Research Technology Center Poster from 2006 ISSX meeting
High-Throughput Mass Spectrometry-Based Screening to Identify Selective CYP3A5 Inhibitors

RapidFire Application Note
CYP Inhibition Screening: Achieving Consistent High-throughput Data Across Mass Spec Platforms

RapidFire Application Note
Evaluation of High-throughput Screening Methods for Time Dependent Inhibition of CYP3A4 Utilizing RapidFire LC/MS/MS Technology

Customer Case Study
Delivering an Ultra High-throughput P450 Inhibition Assay

Lead Discovery Publications

RapidFire Poster: Epigenetic Targets
High Throughput Mass Spec Detection of Histone 3 Demethylation

Authors Tom Holt et al, Merck, Assay Drug Dev Tech 2009 Oct;7(5)
Label-Free High-Throughput Screening via Mass Spectrometry: A Single Cystathionine Quantitative Method for Multiple Applications

Authors Erik F. Langsdorf et al, Schering-Plough, J Biomol Screen, 2010 Jan;15(1)
Screening for Antibacterial Inhibitors of the UDP-3-O-(R-3-Hydroxymyristoyl)-N-Acetylglucosamine Deacetylase (LpxC) Using a High-Throughput Mass Spectrometry Assay

Pfizer Presentation at 2008 SBS meeting
The Use of High Throughput Mass Spectrometry (HTMS) in Drug Discovery

Amgen Presentation at 2008 Protein Society meeting
Screening For ATP Citrate Lyase Inhibitors Using Mass Spectrometry

Merck Presentation at 2007 SBS meeting
Identification of Inhibitors for the Phosphatidylethanolamine N-methytransferase Enzyme by High-Throughput Mass Spectrometry Detection of Reaction Products

Bayer Presentation at 2007 SBS meeting
High-Throughput Mass Spectrometry Screening for Inhibitors of Phosphatidylserine Decarboxylase

Schering Plough Research Institute Poster from 2006 SBS meeting
Screening LpxC (UDP-3-O-(R-3-hydroxymyristoyl)-GlcNAc deacetylase) using RapidFire® HTS Mass Spectrometry

Pfizer Poster from 2006 SBS meeting
Identification of Fatty Acid Amide Hydrolase Inhibitors by a High Throughput Mass Spectrometry-Based Assay

Bayer Poster from 2006 SBS meeting
Label-Free High-Throughput Screening by Mass Spectrometry

Sirtris Pharmaceuticals Poster from 2006 SBS meeting
Development of a High Throughput SIRT1 Mass Spectrometry Assay

BlueSky BioTech Poster from SBS 2006 meeting
Label-Free Screening of Acetyl-CoA Carboxylase from an Enriched Rat Liver Fraction

BlueSky BioTech Poster from SBS 2006 meeting
Label-Free Screening of Stearoyl-Coenzyme A Desaturase from an Enriched Rat Liver Fraction

Presentation at 2008 Assay Development & Screening Technologies Conference (GTC Bio meeting)
This presentation details the use of the RapidFire® high-throughput mass spectrometry platform in primary drug-screening applications.  Several key examples from the literature are included.
To request a copy of this presentation, click here

Amgen Presentation at 2006 ScreenTech meeting
This presentation details work performed at Amgen validating the RapidFire® high-throughput mass spectrometry platform via comparison to both HTRF and fluorescence polarization technologies.  Screening of the Lck kinase target was used as the basis for this comparion.
To request a copy of this presentation, click here